channel block — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6134	IEM 1754 2HBr	IEM 1754 dihydrobromide	GluR
	IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.		GluR
T10101	Calcium channel-modulator-1		Others , Calcium Channel
	Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.		Others , Calcium Channel
T3543	NS-638	NS 638	Calcium Channel
	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).		Calcium Channel
T13320	VU591 hydrochloride		Potassium Channel
	VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentr...		Potassium Channel
T6186	TRAM-34	Triarylmethane-34,TRAM 34	Potassium Channel , IκB/IKK
	TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450. The selective activity of TRAM-34(TRA...		Potassium Channel , IκB/IKK
T22178L	Spadin Acetate	Spadin Acetate(1270083-24-3 Free base)	Others
	Spadin Acetate is a natural peptide derived from a propeptide released in blood. Spadin Acetate is able to block the TREK-1 channel activity. Spadin Acetate binds specifically to TREK-1 with an affinity of 10 nM.		Others
T2732	(-)-Epicatechin gallate	(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG	Virus Protease , COX , Autophagy
	(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin...		Virus Protease , COX , Autophagy
T12153	N-type calcium channel blocker-1		Calcium Channel
	N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.		Calcium Channel
T25312	Detajmium	Tachmalcor
	Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.
T12373	Paxilline		Others
	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.		Others
T19591	Triamterene D5		Others
	Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.		Others
T16135	MRS 1523		Others
	MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 recept...		Others
T61475	Ropivacaine mesylate
	Ropivacaine mesylate, a long-acting amide local anaesthetic, is used for spinal block and effectively mitigates neuropathic pain. It achieves analgesia by reversibly inhibiting sodium ion influx in nerve fibers, thus blo...
T69652	Relutrigine	PRAX-562
	Relutrigine (PRAX-562), an orally active persistent sodium channel inhibitor, potently and selectively targets persistent I Na, induced either by ATX-II (Nav 1.5 activator) or SCN8A mutation N1768D, with IC 50 values of ...
T35922	NAADP (sodium salt)
	Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then...